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| Single-Season Strikeouts Leaderboard | |
| * - Indicates Hall of Fame |
| Rank | Player | Strikeouts | PA | Year | Career Leaderboard |
| 1. | Francis Edwards | 164 | 667 | 2006 | |
| 2. | Jose Delarosa | 159 | 709 | 2005 | |
| 3. | Lucas Aguilar | 157 | 657 | 2006 | |
| 4. | Luis Hernandez | 147 | 655 | 2006 | |
| Daniel Hernandez | 147 | 654 | 2005 | ||
| 6. | Pelayo Cicero | 143 | 635 | 2005 | |
| 7. | Lucas Aguilar | 138 | 641 | 2005 | |
| 8. | Daniel Hernandez | 132 | 657 | 2006 | |
| 9. | Amadis Gomez | 129 | 594 | 2006 | |
| 10. | Luis Hernandez | 128 | 635 | 2005 | |
| 11. | Jose Delarosa | 120 | 595 | 2006 | |
| 12. | Fernando Valdez | 119 | 625 | 2006 | |
| Angelo Cordova | 119 | 602 | 2006 | ||
| Julio Echague | 119 | 595 | 2006 | ||
| Angelo Cordova | 119 | 536 | 2005 | ||
| 16. | Angel Cataldo | 118 | 490 | 2005 | |
| 17. | Robert Mutsuhito | 117 | 614 | 2005 | |
| 18. | Marion Tedesco | 115 | 584 | 2005 | |
| 19. | Christopher Auman | 114 | 554 | 2005 | |
| 20. | Robert Mutsuhito | 113 | 527 | 2006 | |
| 21. | Scot Wright | 112 | 655 | 2006 | |
| 22. | James Bostic | 110 | 549 | 2006 | |
| Christopher Auman | 110 | 471 | 2006 | ||
| Leopoldo Terrazas | 110 | 544 | 2005 | ||
| 25. | Kenneth Bernard | 109 | 710 | 2006 | |
| 26. | Rick Sarabia | 108 | 574 | 2005 | |
| Dario Lueras | 108 | 480 | 2005 | ||
| 28. | Gary Marquardt | 107 | 621 | 2006 | |
| Victor Rabe | 107 | 608 | 2006 | ||
| Terry Bell | 107 | 603 | 2005 | ||
| Herbert Cole | 107 | 574 | 2005 | ||
| 32. | Nathan Prioleau | 106 | 660 | 2006 | |
| Freddie Mendez | 106 | 570 | 2006 | ||
| Francis Edwards | 106 | 538 | 2005 | ||
| 35. | Tony Cuellar | 105 | 663 | 2006 | |
| Pelayo Cicero | 105 | 520 | 2006 | ||
| Julio Echague | 105 | 496 | 2005 | ||
| 38. | John Altizer | 104 | 565 | 2006 | |
| Joseph Chico | 104 | 633 | 2005 | ||
| Edward Hambleton | 104 | 595 | 2005 | ||
| Thomas Blalock | 104 | 564 | 2005 | ||
| Ramon Jimenez | 104 | 446 | 2005 | ||
| 43. | Herbert Cole | 103 | 608 | 2006 | |
| Leopoldo Terrazas | 103 | 579 | 2006 | ||
| Phillip Patrick | 103 | 631 | 2005 | ||
| Fernando Valdez | 103 | 586 | 2005 | ||
| 47. | Gregory Oakes | 102 | 595 | 2005 | |
| Stephen Tierney | 102 | 587 | 2005 | ||
| Robert Dorsey | 102 | 571 | 2005 | ||
| 50. | George Ferraro | 101 | 619 | 2006 | |
| Edward Kennison | 101 | 578 | 2005 | ||
| Andre Molina | 101 | 430 | 2005 | ||
| 53. | George Ardis | 100 | 642 | 2006 | |
| Frank Rosenthal | 100 | 642 | 2006 | ||
| Pedro Romero | 100 | 628 | 2006 | ||
| 56. | Duane Lizarraga | 99 | 700 | 2006 | |
| Manny Magdaleno | 99 | 653 | 2005 | ||
| 58. | Phillip Patrick | 98 | 645 | 2006 | |
| Marion Tedesco | 98 | 440 | 2006 | ||
| Richard Blakney | 98 | 551 | 2005 | ||
| Melvin Maranto | 98 | 490 | 2005 | ||
| 62. | Stuart Waterfield | 97 | 568 | 2006 | |
| Allen Farrell | 97 | 562 | 2006 | ||
| Lucas Guzman | 97 | 479 | 2006 | ||
| Carl Hartnett | 97 | 567 | 2005 | ||
| 66. | Roosevelt Belden | 96 | 663 | 2006 | |
| Victor Ronk | 96 | 647 | 2006 | ||
| Steve Gibson | 96 | 620 | 2006 | ||
| Bill Bakken | 96 | 574 | 2006 | ||
| Terry Morris | 96 | 465 | 2006 | ||
| Leon Casas | 96 | 607 | 2005 | ||
| John Felice | 96 | 601 | 2005 | ||
| Victor Rabe | 96 | 591 | 2005 | ||
| 74. | Lorenzo Ucelay | 95 | 669 | 2006 | |
| Jessie Evans | 95 | 627 | 2006 | ||
| Alberto Caminos | 95 | 607 | 2006 | ||
| Gerald Miller | 95 | 514 | 2006 | ||
| James Gates | 95 | 637 | 2005 | ||
| Jack Morelli | 95 | 581 | 2005 | ||
| Kelley Hershberger | 95 | 540 | 2005 | ||
| Miguel Samaniego | 95 | 511 | 2005 | ||
| 82. | Edward Hambleton | 94 | 650 | 2006 | |
| Gregory Oakes | 94 | 551 | 2006 | ||
| Matthew Woods | 94 | 507 | 2006 | ||
| Joshua Bombard | 94 | 492 | 2006 | ||
| Dario Lueras | 94 | 479 | 2006 | ||
| Sabino Colmenares | 94 | 431 | 2006 | ||
| George Ardis | 94 | 628 | 2005 | ||
| Ryan Kangas | 94 | 594 | 2005 | ||
| Lucio Rios | 94 | 504 | 2005 | ||
| Carlos Santillo | 94 | 477 | 2005 | ||
| Sabino Colmenares | 94 | 425 | 2005 | ||
| 93. | George Olivera | 93 | 608 | 2006 | |
| Jarrod Watson | 93 | 546 | 2006 | ||
| Thomas Blalock | 93 | 541 | 2006 | ||
| Samuel Mitchell | 93 | 501 | 2006 | ||
| Eric Champion | 93 | 657 | 2005 | ||
| Allen Farrell | 93 | 608 | 2005 | ||
| Jefferey Roberson | 93 | 392 | 2005 | ||
| 100. | Albert Sanches | 92 | 658 | 2006 |
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